Melanoma - skin cancer reviewed

Skin Structure, Skin Image ProcessingApril 27, 2006 7:32 am
This pilot study is intended to investigate possibilities of skin nevus imaging using digital still image camera. The main objective is to develop method of dermatology images interpretation, which enables the looking on the skin lesions and nevus from the optical background of skin coloration. Kubelka-Munk calculation method for light transport and reflection from multilayered complex media is applied in modeling of light reflection spectra of skin. Calculation of model shows that red, green, blue and infrared colors lighting is satisfactory to access distribution of comparative estimates of the following skin parameters: volume fraction of melanin in epidermal layer, volume fraction of hemoglobin in dermal layer, presence of dermal melanin and thickness of papillary layer. Performance of image processing method on fourteen samples of images of common melanocytic nevi, dysphasic melanocytic nevi, Spitz nevus, thrombotic hemangioma and surrounding healthy skin were made.

Skin spectral properties

Understanding how light interacts with skin, can assist in designing physics based dermatological image processing. The key is understanding how light interacts with skin tissue. Skin consists of different layers with different spectral properties.
Skin spectral properties
Fig 1. Skin model and its physical view
Whent incident light is applied to skin layer, the part of it absorbed and other part is scattered. The main layers of skin are as as follows: Stratum cornea it practically doesn’t absorb light, but diffuses it; Epidermis consists of cels producing pigment melanin. Melanin strongly absorbs strongly absorbs light wavelengths towards ultraviolet part; Dermis is next skin layer which consists of collagen fibetrs. It can be split in to two sublayers: Papilary dermis and dermis itself. Papillary dermis consists of high dence of collagen fibbers who is strong scatterer of light.

Implementation of skin spectral model

Skin is modeled as two light fluxes through three layer media. As Kubelka Munk theory says, Incident light fluxe is resoved into two fluxes: one is directed in to deeper layers, and other is opposite directed because of back scattering.
Kubelka-Munk skin layers 
Because of layered skin structure, there are multiple reflections. Thei can be solved as infinit sum:
Skin reflectance 
For N layer system, R1,2…n and T1,2..n is expressed as recursive equations:
Skin transmitance
Reflectance from skin
The main model requirement is that light has to be scattered. Stratum cornea is supposed as scattering filter. According to earlier studies skin can be characterized as follows:
1) Epidermis, depending on wavelength can be characterized with melanin absorbtion coefficient μam(λ) and melanin concentration cm;
2) Papillary dermis can be described with hemoglobin absorbtion coefficient μah(λ), hemoglobin concentration ch, collagen scattering coefficient μspd and collagen layer thickness dpd;
3) Dermis can be described with scattering coefficient μsrd and thickness of layer drd.

Using those parameters the model of skin was calculated which shows reflected light R(λ) dependency on skin parameters and wavelengths of light:
 Skin reflectance calculation algorithm
Ranges of volume fraction of melanin cm –are in range for normal healthy skin: 0,01 – 0,5; ch – hemoglobin volume fraction coefficient, in model: 0,001 – 0,05.
RR(λ), RG(λ), RB(λ) are reflectance spectras for red, green and blue illumination. SLEDR, SLEDG, SLEDB – light source spectral charecteristics; SCCDR, SCCDG, SCCDB – CCD sensor sensitivity to light wavelength.
After these calculations, we get one RGB vector pointed to one point in RGB space for one independent set of parameters:
Skin RBG Colors 
All vector values is displayed in RGB space drawing a color surface of all available healthy skin colors
Skin color space. Skin RGB 
This model is valid for all healthy skin, where is no melanin presence in papillary dermis. This model does not depend on race or even on sunburn degree.
 
Skin StructureMarch 24, 2006 8:27 am

According to earlier modeling description, there were skin reflectance spectra calculated for skin with most common properties: Melanin (volume fraction 2% in Epidermis); hemoglobin HbO2 and Hb (150 g Hb/liter ) and Thickness of collagen tissue in papillary dermis about 0.1mm.

Skin spectral properties 

What are the parts of this spectrum? This spectrum can be exploded in to several distinct spectra’s: Epidermis, Hemoglobin, There are also spectra’s of water and collagen substances, but they doesn’t play main role in our wavelength interval.

Skin reflectance spectra 

 As you can see melanin in epidermis absorbs the most part of blue light ~470nm; hemoglobin absorbs green light ~252nm and red light ~640nm and infrared 850 are used to define papillary dermis thickness, because these wavelengths are less absorbed by melanin and hemoglobin.

MM 

Skin StructureMarch 22, 2006 12:33 pm

Skin is very intelligent structure of our body. It is very elastic and pretty strong to protect inner tissue. It also acts as thermo regulator of our entire body protecting from overheats when we sweat and when there is cold – the blood flow is reduced to skin tissues to save heat to inner organs of body.

Skin is pretty resistive to harmful chemicals, microorganisms and if dry it has high electrical receptivity. From biochemical side – skin can produce vitamin D when exposed to sunlight, which is essential for the growth and maintenance of our bones. The extensive network of nerves within the skin feeds information constantly to the brain concerning our surroundings. So it is full of sensors to know the external world like temperature, pressure. Don’t even let me start about skin importance in fashion industry. About how much there is attention paid to cosmetics, beauty shine. Skin can show you if you’re shy or cold or afraid. As you see, skin top layer of your body, and it can tell you so much and tell you many things, just get to know it.

Lets do it…

skin structure diagram

Mainly people used to name only two layers of skin epidermis and dermis. But in reality there more layers with own properties. In some cases dermatologists describe there even more layers of sub layers. I am going to be in the middle of this. Lets see the skin structure first:

skin structure diagram 

So wee can see histological cut of skin layer. There are layers as follows:

  • Stratum cornea;
  • Epidermis;
  • Papillary dermis;
  • Reticular Dermis;
  • Hypodermis.

Little bit about all of them:

Stratum cornea

It is the most top skin layer of dead cells. These cells are keratin impregnated and protect the skin surface. As well se later in my articles it also acts as light diffuser. Then follows more important skin layer

Epidermis

Epidermis is about 0.1mm thick. It mainly consists of connective tissue and cells so called melanosomes who produce pigment melanin. The most interesting part is melanosomes and melanin. Melanin is pigment, which protects you deeper organs from hazardous Ultraviolet light.

 melanocytes

White people got less of them; people with dark skin have more of them. In summer time when you get sunburn, you get darker, because your skin is trying to protect you from harmful ultraviolet light. This is why you should be very careful when taking sunbathes in springtime or in the beginning of summer, because your skin isn’t ready for taking much sunlight. Little by little taking sunbathes your skin produces more melanin, then you are more protected. People in Africa have dark skin – guess why?

Lets leave Epidermis go to Dermis side.

Papillary dermis

Papillary dermis interconnects with epidermis. It consists of dense collagen tissue this is why mainly almost all light is reflected from this layer. Papillary dermis supports the epidermis with vital nutrients and secondly to provide a network for thermoregulation. There is nor or there is very little of melanin pigment on this layer.

Reticular dermis

 This layer consists of dense irregular connective tissue, which differs from the papillary dermis, which is made up of mainly loose connective tissue. The reticular layer of the dermis is important in giving the skin it overall strength and elasticity, as well as housing other important epithelial derived structures such as glands and hair follicles.

Hypodermis

The subcutaneous tissue (hypodermis) is the deepest layer of the skin. It is missing on parts of the body where the skin is especially thin-the eyelids, nipples, genitals, and shins. Subcutaneous tissue acts both as an insu­lator, conserving body heat, and as a shock absorber, protecting in­ternal organs from injury. It also stores fat as an energy reserve in the event extra calories are needed to power the body. The blood vessels, nerves, lymph vessels, and hair follicles also cross through this layer.

That’s it skin structure diagram section this time. Follow next articles.

MM

 

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