Melanoma - skin cancer reviewed

Melanoma ArticlesApril 4, 2006 5:40 pm

To improve diagnostic accuracy the  ABCD rule of lesion screening is widely used based on  asymmetry (A), border (B), color (C), and differential structure (D) measuring.

•         A total dermatoscopic value (TDV) results from the calculation

TDV = A·1,3 + B·0,1 + C·0,5 + D·0,5


•         This score contributes to the differentiation between benign and malignant lesions:


                                           1,00  -  4,75 – benign skin lesion


                                           4,75  -  5,45 – suspicious


                                           More than 5,45 – melanoma


Asymmetry


A – Asymmetry of Shape, Structure and Color. The lesion is divided in four regions and there is symmetry inspected across x or y axis. If asymmetry is only by one axis it gives 1 point and if on both axis there are 2 points calculated. So for shape, structure and color, there can be 6 points maximum.

Melanoma assumetry

 


Border and Color


For measuring border irregularities the lesion is divided in 8 regions. If in one particular region color is ends strictly with boundary of lesion there is one point. If lesion color changes smoothly to skin color then there is 0 points. So for B there can be maximum 8 points.


For color there can be as many points as many colors there can be found on lesion. Usually there are 6 main colors, so total 6 points for C.

Lesion border and color

 


Dermatological Structure D


Thera are 5 main structures noticed in lesions. No structures – smooth color – 1 point, net structure another 1 point, tree like boundaries another 1 point, dots – 1 point and globules 1 point. Total 5 points can be. In some literature there can be diameter of lesion measured for D. If diameter is more than 6 mm it can be stated as suspicious.

Dermatological structures

 


When looking in Total Dermatological Value formula, there are obvious that the main criteria are Asymmetry. It is usually the main screening option.  It is easy to inspect yourself using this methodology. If there is any concern, it is better to visit your doctor.

 

Skin Image Processing 5:10 pm

    There are many skin image capture methodologies developed and used. Here are short review of them:

Dermatoscopic photography

The deepest layer of skin can be reached - Papillary dermis

Resolution – depends on optical system

View of skin – Horizontal

The main disadvantage is reflections of light from skin surface – stratum cornea.

 Skin photography

 

Dermatoscopic oil immersion photography

The deepest layer of skin can be reached - Papillary dermis

Resolution – depends on optical system

View of skin – Horizontal

Reflections of light from skin surface are smaller because of oil used between camera optics and skin.

Oil immersion 

Fluid free dermatoscopic photography, polarized light

This method gives similar results as using oil immersion. It is cleaner image taking method, because sin is kept dry and there is no wet contact with camera.

Trimodal light source

    The deepest layer of skin can be reached - Papillary dermis

    Resolution – depends on optical system

    View of skin – Horizontal

This is special method of light directing to deeper skin layers avoiding passing the lesion surface. It gives very good results of skin deeper layer imaging.

Epiiliuminescence skin imagingTrimodal photography

 

CSLM

    CLSM  - laser scanning microscope system. There laser beam is focused to particular skin layer and     scanned 2D image in this deep. This method is handy when taking deeper layers of skin. The deep can be from 2 to 300ukm.

CSLM laser scannig Laser scanning of skin

Multispectral dermatoscopy

 Multispectral skin photography

This method is described in earlier articles. There are multispectral light used to take separate pictures. Then calculation is used evaluate pigmentation of different skin layers. This is progressive methodology in diagnosis.

Optical Coherence Tomography

 

There is interference of two different light sources. One is directed to skin and other is reference to determine the depth. This method is more advanced and not suitable for screening. The depth can be achieved - 15 - 2 μm.

Optical kocherent tomographyOptical cocherent photography

High Resolution Ultrasonic Imaging

    There is high frequency ultrasound used to determine lesion boundaries before surgery. In early skin cancer detection this method hardly can be used, as the difference between healthy and suspicious regions are minimal. But combining Ultrasound and lets say multispectral photography can show good results.

Ultrasound skin imaging 

 

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